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GLP-1RAs and other incretin-based NuSHs, by ameliorating hepatic lipotoxicity, improving insulin sensitivity, and reducing inflammation, may help restore a more functional immune milieu

These medicationsincluding semaglutide (injectable Ozempic, oral Rybelsus, injectable Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)mimic the action of endogenous GLP-1 while resisting degradation by the enzyme dipeptidyl peptidase-4 (DPP-4)

This makes GLP-1 injections a highly effective, non-surgical option for long-term weight management, especially when combined with a healthy diet and regular exercise.

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