Since brain GLP-1R signaling is to a large extent directly triggered by its peripheral secretion from the intestines via vagal stimulation of the NTS neurons, it seems plausible that proper balance in gut microbiota abundance and diversity can influence action of this peptide in the central nervous system
The drugs bring people to their factory settings by mimicking the GLP-1 hormone, which the body uses as a signal to help the brain decide when to stop eating and when to seek out more food
Bergmann NC, Lund A, Gasbjerg LS, Meessen ECE, Andersen MM, Bergmann S, Hartmann B, Holst JJ, Jessen L, Christensen MB, et al
Single-strain probiotics can't survive the extended transit time
This unified, single-point-of-contact approach brings significant production benefits to pharma partners through minimising the number of friction points that can be present in a more fragmented supply chain and ensuring that all components ultimately knit together into a coherent combination product
For someone on a GLP-1 medication where transit time is already extended, this can make the difference between a comfortable daily bowel movement and going 3-4 days without one
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