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Underland et al [23] performed a randomised, double-blinded, placebo-controlled study to assess the role of 100 mg of sitagliptin as an add-on therapy in type 1 diabetes with an insulin-only closed-loop system for 25 h with timed meals

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Anti-TPO antibodies from healthy subjects did not block TPO activity or interfere with the blocking activity of anti-TPO antibodies from AITD patients (24), while anti-TPO antibodies from AITD patients can fix complement, destroy thyrocytes, and act as competitive inhibitors of enzymatic activity (25)

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