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Patients are often surprised to learn that this dose isnt universally necessarysome continue to see success at 1.7 mg, while others feel better staying at 1 mg due to tolerability

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Peer review Peer review information Nature Communications thanks Guanghui Tang and the other anonymous reviewers for their contribution to the peer review of this work

Extracellular osmolarity of medullary cells may become more than four-fold that of isotonicity [50]

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