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Oxidative Stress in Aging Human Skin

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The candidate agents extend current antibiotics classes with, for example, second-generation polymyxins (MRX-8 and upleganan, both in Phase I), an aminoglycoside (apramycin, Phase I), a tetracycline (zifanocycline, Phase I) and a macrolide (nafithromycin, Phase II) as well as new beta-lactam/beta-lactamase inhibitor (BL/BLI) combinations (ceftibuten/ledaborbactam, Phase I

The ROS generation was detected with a Leica fluorescence microscope (Leica DM6000B) using Leica LAS X software, and quantitative analysis was performed with ImageJ software (version 1.60

Glutathiones antioxidant and anti-inflammatory properties help preserve collagen and elastin fibers, maintaining skin elasticity