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Funding This research was supported by the Natural Science Foundation of Zhejiang Province (LR25H310006), the National Natural Science Foundation of China (82474126), and the Zhejiang Province Traditional Chinese Medicine Key Laboratory Project (GZY-ZJ-SY-2303)

Wnt/-catenin signaling is a master regulator of hair cell (such as hair matrix cell, outer root sheath cell (ORSC) and derma papilla cell) proliferation and migration and promotes cell-cell adhesion 16,19

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This is remarkable because current pharmacological treatments for frozen shoulder are entirely palliative

Drugs including Erastin and sorafenib, which induce ferroptosis by inhibiting the system x c , are promising anticancer therapeutics [13, 14]

Cartilage Repair and Regeneration One of the most exciting aspects of BPC-157 is its potential to promote tissue repair and regeneration