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Costa et al., 2023)

Studies have highlighted concerns regarding the potential increased risk of breast cancer, cardiovascular disease, and thromboembolic events associated with long-term HRT use [86]

however, the coefficients for all variables (both case and control) were not statistically significant, suggesting that these demographic factors do not have a meaningful impact on WL in this context

Bremer, J

Through -glucuronidase activity, gut microbes deconjugate bound androgens, increasing circulating free testosterone levels ( Clinically, PCOS patients exhibit reduced gut microbial -diversity, an elevated Bacteroidetes-to-Firmicutes ratio, and decreased abundance of beneficial bacteria such as Akkermansia muciniphila

The degradation of heme and release of iron by the reaction with GSH was first described by Atamna and Ginsburg to occur in membranous bound heme at physiological pH [25]