Collectively, these data raise the possibility that the GSK3-CaMKK2-CaMK4 signalling axis is a principal site of action through which lithium increases BDNF expression and exerts its anti-manic effects
Functional categories with a P -value 0.05 were considered significant, and relevant results were visualized using the ggplot2 (v3.5.1) package in R
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PubMed National Institutes of Health Office of Dietary Supplements
Este cambio metablico se debe a la accin del pptido sobre la va de metilacin de la nicotinamida , que aumenta la disponibilidad intracelular de NAD+, facilitando as un mayor metabolismo oxidativo
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