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Risk reduction In a trial of 17,000 adults, those taking the drug Wegovy were less likely to experience nonfatal heart attacks, nonfatal heart strokes or death due to cardiovascular causes than those taking a placebo

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10% 43 , respectively)

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Furthermore, the study demonstrated functional clinical benefits: natural killer (NK) cell cytotoxicity, a vital marker of immune system strength, increased more than twofold in the high-dose cohort

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Additionally, if gut permeability is indeed increased in ME/CFS patients, microbes and antigens may be able to cross the epithelial barrier into surrounding tissue and blood, potentially crossing the BBB and altering the HPA axis (443)

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This finding is particularly noteworthy given that some trials extended to 24 weeks of continuous exposure and included participants with obesity-related comorbidities who might be expected to have higher baseline health risks

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