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NAD+ (Nicotinamide Adenine Dinucleotide) is the central coenzyme of metabolism, essential for converting nutrients into energy (ATP)

Efficacy estimand: This analysis was not included in the statistical testing hierarchy, and as such, is hypothetical and was not controlled for multiplicity Study design OASIS 4 7,10 : A randomized, double-blind, placebo-controlled 64-week trial of 307 adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m-29.9 kg/m) and 1 weight-related comorbid condition, such as treated or untreated dyslipidemia or hypertension

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While these conditions differ in underlying causes, both result in joint pain, stiffness, reduced mobility, and progressive tissue damage

There was also no beneficial effect of urolithin A treatment in the absence of sleep deprivation, and its effects on young and old mice were comparable