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however, the increased risk and severity of this complication prompted the EMA to warn patients

Nausea and vomiting rates appeared slightly elevated compared to tirzepatide at equivalent phases of dose escalation

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164 Protein intake in adults should not fall below 0.4-0.5 g/kg/d, as this can lead to muscle atrophy and functional impairments, whereas prolonged intake at or above 2 g/kg/d should be avoided due to potential adverse health effects

2025 The final report published by Proksch et al

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