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[DOI] [PMC free article] [PubMed] [Google Scholar] 169.Egusa H, Kaneda Y, Akashi Y, Hamada Y, Matsumoto T, Saeki M, et al
GLP-1 RA treatment has been associated with enrichment of bacterial genera such as Akkermansia and Bacteroides , which include species with bile salt hydrolase activity and actively participate in bile acid deconjugation (83, 84)
Furthermore, heme can drive TNF-- and ROS-mediated necroptosis [225], heme oxygenase 1-dependent ferroptosis [226], and NLRP3 inflammasome-associated pyroptosis [227], which are highly proinflammatory RCDs
Patients who tolerated the molecule poorly at higher injectable doses Some patients respond well to semaglutide or tirzepatide at lower doses, but struggle with side effects as the dose is increased
Cons: Higher risk of initial stomach upset
Restless leg syndrome, characterized by an irresistible urge to move the legs during rest accompanied by unpleasant sensations, affects 26.155.0% of cirrhosis patients, further disrupting sleep
