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Renal Elimination: Sitagliptin is not extensively metabolized by the liver enzymes cytochrome P450 3A4 and 2C8

Vincenti MP, Brinckerhoff CE

Recent Developments: Roche - Acquisition (December 2023): Roche acquired Carmot Therapeutics, adding dual GLP-1/GIP agonist assets to its pipeline, positioning to compete with Novo Nordisk and Eli Lilly in obesity [1]

SCFAs activate free fatty acid receptors FFAR2 and FFAR3 on L-cells, thereby stimulating GLP-1 secretion

These are two different regulatory frameworks for the same compound