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It is important to note the necessity for cholesterol in maintaining basic neuronal functioning such as myelination, synaptic development and growth, for which the bulk is supplied by astrocytic ApoE (Karahan et al., 2021)
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Its primary mechanism is cellular and chronobiological
Ranging from oxidative stress, and microglial activation to even apoptosis of neurons
The Glyteine concentration in cells at any given time is therefore negligible
Nutrient-driven histone code determines exhausted CD8 + T cell fates
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