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The reduction of human RNR, which was suggested to follow mechanism (ii) 46 , therefore needs to be analyzed and monothiol mechanism (iii) should be also considered
Elfowiris A, Banigesh A
Chen H, Zhao J, Kang Y, Wang S, Qin D, Yu L, et al
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However, as explained by the Alzheimers Drug Discovery Foundation in 2024, while urolithin A does have an impressive safety profile, its long-term safety has yet to be established.4 Also, while rare, some people can be allergic to pomegranates, which are rich in the polyphenols that are metabolized into urolithin A.21 This doesnt necessarily mean that those with pomegranate allergies will have a reaction to urolithin A supplements, but it could be something to keep in mind
Nutrients 16 (11), 1650
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