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Additionally, TGF- (transforming growth factor-beta) signaling is disrupted, which normally regulates cell growth and repair

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Impacts will vary by age, with ages 45-59 seeing the biggest reduction and age 85+ the lowest reduction

While numerous randomized clinical trials substantiate the antidepressant efficacy of Rhodiola, Ginkgo, and Ashwagandha, these investigations are frequently hindered by limited sample sizes, diverse dosing protocols, variability in extract standardization, and insufficient integration of mechanistic biomarkers

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