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Discuss at your next appointment if: you have reached week 8 with zero noticeable appetite or weight changes at your current dose, side effects are manageable but annoying and not improving, you are considering adjusting your dose escalation timeline, you want to explore combination approaches, or you are experiencing insomnia , menstrual changes , feeling unusually cold , or hormonal changes that you suspect are related to the medication

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Nausea, abdominal discomfort, and GI side effects are well-documented with semaglutide and tirzepatide - especially early on or after dose changes

doi:10.1056/NEJMoa2206038 [5]4