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Although GPCRs have conventionally been associated with the activities of specialized, non-dividing cells, they are also present in dividing cells, contributing to processes such as embryogenesis, tissue reconstruction, inflammation, angiogenesis, regular cell proliferation, and even cancer [108, 109]

Synthesis of 3-keto-4-diazo-5--dihydrosteroids as potential irreversible inhibitors of steroid 5--reductase.Tetra.Lett.1980,21, 15-18 75

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While each indication demands rigorous evidence of safety and efficacy, existing clinical platforms show that intracranial biomaterials can be used safely when properly designed