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These medications include: H1 and H2 antihistamines blocks the effects of histamine and reduce symptoms Mast cell stabilizers (cromolyn sodium, ketotifen) prevents mast cells from releasing histamine and leukotrienes Leukotriene inhibitors such as montelukast blocks leukotrienes, inflammatory chemicals released by mast cells Aspirin (only under direct physicians supervision) Omalizumab (brand name Xolair) targets the protein antibody Immunoglobulin E (IgE) to limit the release of histamine from mast cells Tyrosine kinase inhibitors for systemic mastocytosis Tyrosine kinase inhibitors are medications that can help stop symptoms before they start