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This significant level of evolutionary conservation with higher eukaryotes suggests that C

[56] However, fair credit for the first description of Graves' disease goes to the 12th-century Persian physician Sayyid Ismail al-Jurjani, [57] who noted the association of goiter and exophthalmos in his Thesaurus of the Shah of Khwarazm , the major medical dictionary of its time

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They block an enzyme that would otherwise break down cyclic GMP, a molecule that relaxes smooth muscle in blood vessels

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