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Its inverse association with tHcy, though weaker than the other vitamins studied, was only observed in the optimal riboflavin status group and further stratification by folate status showed that the association was restricted to participants with plasma folate below the reference category ( 273 pmol/L)

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GHK-Cu is present in human plasma at approximately 200 ng/mL (roughly 500 nM) in young adults around age 20, declining to approximately 80 ng/mL (roughly 200 nM) by age 60, representing a 60% reduction over four decades

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