Moreover, although GIPR is expressed in the testes in preclinical models, its role in human reproductive physiology appears limited based on gene expression data [211]
10.1210/en.2002-220819 162
Fichadiya H, Bentall A
A once-weekly dosing interval may offer several practical advantages, including: Potentially improved patient adherence compared with daily injections an association observed with other once-weekly incretin therapies, though direct adherence data for retatrutide are not yet available Relatively stable plasma drug levels between doses, which may help reduce the peaks and troughs that can contribute to side effects Consistent pharmacodynamic effects throughout the week, supporting sustained appetite suppression and metabolic activity In Phase 2 trials (Jastreboff et al., NEJM , 2023), retatrutide was studied across a range of doses up to 12 mg once weekly, with structured dose-escalation protocols used to improve tolerability a strategy commonly employed with incretin-based therapies to minimise gastrointestinal side effects such as nausea, vomiting, and diarrhoea during initiation
The recommended dosing includes a slow titration to reduce the incidence and severity of these adverse effects
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