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The highest approved dose is 2 mg weekly , designed for those who need stronger blood sugar management and can tolerate the higher dose

Colhoun HM, Betteridge DJ, Durrington PN, et al

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Chapman LE, Darling AL, Brown JE (2015) The association between the biguanide drug metformin and vitamin B 12 deficiency in diabetic patients: a systematic review

Additionally, semaglutide has shown potential to reduce the risk of major cardiovascular events such as heart attacks and strokes, particularly in adults with type 2 diabetes and existing cardiovascular conditions

Accordingly, if 50 patients were required for the maintenance phase, at least 100 patients would be required for the induction phase