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GLP-1 and Appetite Regulation: The Role of Brain-Gut Signaling GLP-1 is not only produced in the gut but also acts in the brains hypothalamus, where it influences hunger and satiety signals

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Fluoro-Jade C-positive foci were scored across entire coronal sections of brain and the number of 40x fields containing either single or multiple foci were quantified relative to the Sham control group