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Key findings from clinical trials include: Slight increases in heart rate were noted, with mean increases of approximately 2-3 beats per minute compared to placebo Small reductions in systolic blood pressure (the upper number) were observed in some studies, typically in the range of 1-3 mmHg [1] [2] These blood pressure changes were generally not considered clinically significant for most patients The effects appeared to be more pronounced at higher doses, though individual responses may vary It is important to note that according to the MHRA-approved Summary of Product Characteristics (SmPC), hypertension (high blood pressure) is not listed as a common adverse effect of semaglutide

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