Without GPX4 activator, the downstream metabolites of the 5-LOX, 12-LOX, and 15-LOX pathways were markedly elevated after A23187 stimulation ( Figure 4 ), compared to the normal state ( Supplementary Figure S2 )
[13] Rheumatoid arthritis [edit] Being a disease-modifying antirheumatic drug (DMARD), azathioprine has been used for the management of the signs and symptoms of adult rheumatoid arthritis
Treatment with troglitazone was shown to significantly reduce lipid peroxidation and mitigate tissue injury in irradiated mouse intestinal tissue [39]
In addition, it exhibits neuro- and cardioprotective properties, along with antitumor and anti-aging effects, and enhances mitochondrial activity
Crit Rev Toxicol
Therefore, the rational use of these mechanisms in the biomedical field to regulate cell ferroptosis and specifically induce tumor cell ferroptosis during tumor treatment is a promising cancer treatment strategy [215]