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The DAPA-CKD (Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease) trial specifically included patients with chronic kidney disease with or without diabetes to receive dapagliflozin and found that these patients experienced a lower risk of ESRD, GFR decline of at least 50%, or death from renal or cardiovascular causes in comparison to placebo [31]

Creatine is the most evidence-backed supplement for supporting lean muscle during caloric restriction (Kreider 2017, ISSN)

patients should be advised to keep their diabetic eye screening appointments up to date

Joshi et al., 2018)