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Considering that LCN-2 could function as a biomechanical and inflammatory sensor in bonecartilage crosstalk, its specific role in IVDD needs to be elucidated ( Fibroblast growth factor-23 (FGF-23) is the first identified osteokine that can bind to the tyrosine kinase FGF receptors (FGFRs) to regulate phosphate and vitamin D metabolism (116)

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But their similarities largely end there