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( a - d ) Metabolic phenotype of chow-fed CON (Gipr AP-GFP ) and Gipr AP-KO mice treated with VEH or acyl-GIP (100nmol/kg)

Ferroptosis is an iron-dependent lipid peroxidation and ROS-induced programmed cell death (PCD) modality that relies on iron-mediated oxidative damage, increased iron accumulation, and free radical production, and a fatty acid supply with increased lipid peroxidation is critical for the induction of ferroptosis 22