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Deficiency can lead to Hashimotos disease and hypothyroidism

Figure 10 Such inflammatory changes potentially cause impaired autoregulation of blood flow (356358), and brain tissue hypoxia (101, 103, 109, 113, 127234, 248256, 266, 297318, 329359)

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was supported by the HBIGS MD fellowship programme

IGF-1 LR3 is used in muscle-focused research to probe possible interactions with this pathway: Myostatin Counter-Regulation: In preclinical models, IGF-1type signaling has been reported to counteract some myostatin-associated effects on muscle cells, supporting investigations into how anabolic and anti-catabolic signals intersect