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24 , [2022], published by Wiley, under CC-BY license

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Beyond pancreatic -cells, GLP-1R is also found on various other cell types, such as neuronal cells, cardiovascular cells, gastrointestinal smooth muscle cells, and immune cells [10,11,12,13,14,15,16,17] (Fig

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The apparent discrepancy between Melatonins agonist activity and the observed upregulation of MT1 and MT2 mRNA in the present study can be explained by the context-dependent regulatory dynamics of Melatonin receptors in pathological states

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