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The decreased expression of c-kit inhibits the function of ICCs as pacemakers for intestinal peristalsis (23)

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The cornerstone of management is dose titration (start low, go slow)

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Given how hard it is to get these medications for some patients, this can be an attractive alternative, but the FDA has expressed concern at the frequency of -glutide salts turning up in compounded formulations, which are not present in any of the FDA-approved drugs and thus have an unknown safety and efficacy profile

However, its gastrointestinal side effectsparticularly nausea, vomiting, and diarrheacan lead to dehydration, a well-established risk factor for nephrolithiasis