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GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation

Together changes in cholesterol uptake mediated by the LDL receptor and cholesterol efflux mediated by ABCA1 and ABCG1 will maintain cellular cholesterol homeostasis

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The meta-analysis documented an average HbA1c increase of 0.25% after discontinuation, which is clinically meaningful for people managing diabetes