tirzepatide injection site reaction reddit Severe to Managing GLP-1 Injection Site Reactions:

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According to the FDA prescribing information for Mounjaro, nausea occurred in 12-24% of patients (increasing with dose), diarrhea in 7-17%, and vomiting in 2-10%

GLP-1 receptors are expressed abundantly throughout the pancreas, and in response to GLP-1 therapy, the cells of the pancreas proliferate, swelling the organ, and potentially squeezing off ducts, causing inflammation, at least in rats

While these are reports, they have never been substantiated

doi: 10.3824/stembook.1.95.1 Figure 4DTC niche uses Notch signaling to maintain GSCs