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Retatrutide titration: 1mg to 12mg The retatrutide titration protocol tested in Phase 3 trials follows a five-step escalation: Weeks 1-4: 1mg weekly Weeks 5-8: 2mg weekly Weeks 9-12: 4mg weekly Weeks 13-16: 8mg weekly Week 17 onward: 12mg weekly (maximum dose) The dose doubles at each step (with the exception of the 1mg to 2mg increase), which is a faster escalation rate than either semaglutide or tirzepatide

PMID 29480200

Yang DC, Tsay HJ, Lin SY, Chiou SH, Li MJ, Chang TJ, et al

However, the consistency of emerging data in both men and women raises the possibility that these medications may ultimately prove to have direct reproductive effects as well

However, intact HGH also induces hyperglycemia and can lead to insulin resistance when administered chronically in research subjects