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These drugs all contain an SO 2 NH 2 moiety (Figure 1), from which they derive the designation sulfonamides

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4,312 Dysfunctional retrograde transport of neurotrophins from distal axons to neuronal cell bodies contributes to neuronal degeneration

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Key Clinical Findings The initial draft found that both agents, when added to lifestyle modification, produced significant weight loss, improvements in obesity-related comorbidities, and reductions in cardiovascular risk factors