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Because like charges repel each other, the chondroitin chains fan out, creating massive microscopic spaces within the proteoglycan structure

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HOMA-IR (Calculated) What it measures: A calculated estimate of insulin resistance using fasting glucose and fasting insulin: (Glucose x Insulin) / 405

The TECOS trial showed no difference between the placebo and a sitagliptin group (Table 2) [47,48,49]