Related studies have demonstrated that GLP-1R activation upregulates in situ expression of fibroblast growth factor-7 (FGF7) in intestinal tumor cells, promoting tumor progression and inducing intestinal hyperplasia
Jenn and I discuss: How natural GLP-1 production can decline with age Why under-fueling is still the primary issue for many athletes Different types and forms of GLP-1 meds Who should (and shouldn't) consider these medications Potential risks of GLP-1 use, including muscle loss, bone density loss, and GI distress Potential benefits to inflammation, autoimmune conditions, gut health, and mood Nutrition and supplement strategies when appetite is lower Dosing and microdosing for therapeutic use, not just weight loss Why some athletes cycle on and off these meds, or may only need them for a short period of time Why Jenn takes most clients off GLP-1s during race training The stigma around GLP-1 use among athletes Jenn's own story: early menopause, a cardiovascular family history, and how a short course changed her running Why solid diet and lifestyle habits must always come first I hope this episode helps you better understand the complexities of GLP-1 medications in endurance athletes, and why there's rarely a simple yes-or-no answer to the questions we explore together
Waist circumferencea clinical surrogate marker for abdominal and visceral fatdecreased by approximately 14-18 cm (5.5-7.1 inches) in a dose-dependent manner over the treatment period
And now, people taking GLP-1 medications are reporting unexpected shifts in their mental state: I wasnt expecting it, one woman told me, but I suddenly felt calmer
Keep a simple log of: What you eat and when Your medication timing and dose Daily energy levels This will help you start to spot connections
These standards are critical because semaglutide is a peptidea short chain of amino acidsthat must be injected
