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In the clinical trials upon which FDA approval was based, at 1 and 2 years post-surgery, 75 percent of patients had an improvement in their visual acuity of two lines of more, 60 percent improved their vision by three lines, and 40 percent had a four-line improvement on the eye chart (Hudson 2008 and www.accessdata.fda.gov)

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Consequently, this results in events such as T-cell death, reduced cytokine production, T-cell destruction, and the development of tolerance to antigens, thereby allowing tumors to escape immune detection [109]

therapies are largely symptomatic and directed at palliation rather than correction of the underlying immune dysfunction

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