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It was considered that an increase in antioxidant glutathione levels indirectly suppresses MMP activity as the ROS could participate in the activation of MMPs (Fu et al

The -glutides have been proven to reduce risk of cardiovascular events, while -enatides have not

In contrast to GIP, GLP-1 was found to retain its insulinotropic effect in patients, and this fact provides part of the background for the clinical use of GLP-1 receptor agonists in diabetes treatment