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Reduced MTHFR activity reduced methionine regeneration reduced SAM production reduced methylation capacity across all SAM-dependent methyltransferase reactions consequences that propagate through epigenetics, neurotransmitter metabolism, creatine synthesis, phosphatidylcholine production, and the broader biochemistry that SAM sustains

Key Takeaways A promising hypothesis meets a hard endpoint What did the Alzheimers trial actually show

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A: This depends on your states statute of limitations , but generally you have 2-4 years from when you discovered (or should have discovered) your injury