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Common examples include insulin-dependent diabetics taking short-acting and intermediate-acting insulin, and medications for high blood pressure like ACE inhibitors (lisinopril) and angiotensin receptor blockers (losartan)

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Mech Ageing Dev 198:111545 Li F, Turan V, Lierman S, Cuvelier C, De Sutter P, Oktay K (2014) Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death

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Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells

This creates a tent of tissue that ensures the needle enters the subcutaneous layer rather than going too deep