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Multiple clinical trials in photoaged skin (sun damage) have shown that topical GHK-Cu formulations improve skin appearance including reductions in fine lines and wrinkles, improvement in skin firmness and elasticity, enhancement of skin texture and smoothness, increase in skin thickness (reversing age-related dermal atrophy), improvement in skin clarity and reduction in hyperpigmentation, and overall rejuvenated appearance

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and celecoxib was demonstrated to alleviate ulcerative colitis in mice by inhibiting ferroptosis, suggesting it might also have the potential to modulate the ferroptosis process in OA (Li et al., 2024)

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