In contrast, the specific FTH gene knockout of the mouse proximal tubules could exacerbate renal damage in rhabdomyolysis or cisplatin-induced AKI (Zarjou et al., 2013)
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Apart from the chronotropic effects, direct effects of GLP-1 specifically on the heart have not been comprehensively documented, although evidence exists to suggest that GLP-1 RAs may improve cardiac output as well as cardiomyocyte survival (Ravassa et al., 2012
Studies in rodent models with induced hindlimb ischemia, for instance, are used to evaluate its potential to stimulate collateral vessel formation and restore blood flow to compromised tissues