doi: 10.1093/jmcb/mjaa049 266 PamiesD.SartoriC.SchvartzD.Gonzlez-RuizV.PellerinL.NunesC.et al
Key findings include: GLP3 monotherapy achieved 22.8-24.2% mean weight reduction at 48 weeks in phase 2 obesity trials (8-12 mg doses) Cagrilintide monotherapy produced 10.8% weight loss over 26 weeks in phase 2 studies (2.4 mg dose) CagriSema combination (cagrilintide + semaglutide) achieved 20.4% weight loss at 68 weeks in phase 3 REDEFINE trials Combination approaches consistently outperformed single-agent therapies across multiple dose ranges Studies demonstrated that 100% of participants receiving GLP3 8 mg or higher achieved at least 5% weight loss, with 75-83% achieving 15% or greater weight reduction[9]
Previously, we have shown that C2C12 mouse myoblasts genetically modified to express human LMNA (hLMNA) gene bearing R482L mutation exhibited alterations in coordination of cell cycle dynamics and muscle differentiation, mitochondrial uncoupling, and a decrease in glycolytic activity in skeletal muscle myofiber 18,19,20
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