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Additional exclusion criteria included a history of seizures or seizure disorders, or an ASD diagnosis in the presence of normal EEG findings

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Generation of cellular ROS production, decrease in nitric oxide bioavailability, and activation of enzymes like NADPH oxidase, and many signaling factors induce oxidative stress followed by breakdown of redox balance with consequential development of physiological and metabolic disorders, including endothelial dysfunction, inflammation and increasing concentration of VSMCs

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