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J Diabetes Metab Disord 24 , 33 (2025)

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T3 suppression on GLP-1 / GIP / glucagon agonism caloric deficit and hepatic energy expenditure together downregulate T4-to-T3 conversion

Diabetes (2006) 55:303846.10.2337/db06-0730 30 GagnonJBaggioLLDruckerDJBrubakerPL

Dose Range: 510 mg daily (standard)

Requirements of vitamin B12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with intranasal or oral supplementation