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A RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis

1 Introduction Historically, the diagnosis, prevention, and treatment of disease has originated from research mostly conducted on male cells, male animals, as well as men ( Actually, accumulating evidence has revealed intricate differences in disease prevalence, severity, and outcomes between men and women ( Efforts are being made to elucidate the factors contributing to sexual dimorphism in health and disease

The number of migrated cells remarkably decreased when ERK1/2 signal pathways were blocked by its inhibitor PD98059 (Figure 7BC)

By William Misner Ph.D