Mechanism Avg % weight loss (placebo subtracted) Dosing Side effects Cost Semaglutide GLP-1 receptor agonist : (increases insulin secretion, suppresses appetite, enhances satiety, slows gastric emptying) STEP 1 14.9% (68 weeks) STEP 5 (120 weeks): -16.5% ~1517% average sustained loss 20% loss in ~17% of users 2.4mg weekly Nausea (44%) Diarrhea (30%) Vomiting (24%) Constipation (23%) Headache, fatigue Varies widely but generally the cheaper of the two
Incorporating glutathione skin care products can help neutralize these free radicals, reducing the risk of sunburn and photoaging
2 Since not all individuals with prediabetes progress to T2DM, the use of this term in its strictest sense has been questioned, and some prefer to use the term intermediate hyperglycemia
Age appears to have minimal impact on 3-month results within the trial population
It can change the direction of the conversation about which drug to take
If scar tissue or fibrosis is a concern, adding TB-500 may aid collagen remodeling
