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Why each option is used, how long its needed, and what you should expect as levels normalize

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Notably, GSH depletion and/or GPX4 downregulation have also been linked to pathological oxidative stress in vivo, such as ischemia/reperfusion cardiac injury and doxorubicin induced cardiomyopathy 41, 42

115 In addition, MMP inhibitor was confirmed to significantly attenuate APAP-induced parenchymal and microvascular injury, which implied MMP as a promising intervention target

Despite substantial progress, UPS-based therapies face key obstacles, including achieving substrate specificity and efficient CNS delivery

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